Übersichtsarbeit
Uwe Wollina
Ästhetik des Gesichts. Ein narrativer Review zur Anwendung transkutaner dualer Laser 2015-2025
Aesthetics of the face. A Narrative Review on the Application of Transcutaneous Dual Lasers 2015-2025
Keywords | Summary | Correspondence | Literature
Keywords
Dual laser systems; acne, skin aging; hyperpigmentation, vascular lesions
Schlüsselworte
Duale Lasersysteme; Akne, Hautalterung; Hyperpigmentierungen, vaskuläre Läsionen
Summary
In a narrative review of the last 10 years, the results of dual laser therapies for aesthetically relevant diseases and findings are presented. The combination of two different wavelengths in one treatment makes it possible to offer a tailor-made therapy for different indications, depending on the initial findings. In detail, acne, hyperpigmentation and vascular lesions are discussed. Compared to laser applications with a single wavelength, the literature on dual lasers is limited. Favorable treatment results are reported in particular with the correction of skin aging, circumscribed hyperpigmentation and acquired vascular changes. The results for port-wine stains are divergent. Prospective randomized trials are rare. There is a need for further research.
Zusammenfassung
In einem narrativen Review der letzten 10 Jahre werden die Ergebnisse der dualen Laser-Therapien für ästhetisch relevante Erkrankungen und Befunde dargestellt. Die Kombination von zwei unterschiedlichen Wellenlängen in einer Behandlung erlaubt es, je nach Ausgangsbefund, eine maßgeschneiderte Therapie für verschiedene Indikationen anzubieten. Im Einzelnen werden die Akne, Hyperpigmentierungen und vaskuläre Läsionen besprochen. Im Vergleich zu Laseranwendungen mit einer einzelnen Wellenlänge ist die Literatur zu den dualen Lasern limitiert. Gute Behandlungsresultate werden insbesondere bei Korrektur der Hautalterung, umschriebenen Hyperpigmentierungen und erworbenen Gefäßveränderungen berichtet. Die Ergebnisse beim Nävus flammeus sind divergent. Prospektive randomisierte Studien sind selten. Hier besteht ein weiterer Forschungsbedarf.
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Korrespondenz-Adresse
Prof. Dr. Uwe Wollina
Ehemals Klinik für Dermatologie und Allergologie
Städtisches Klinikum Dresden
Akademisches Lehrkrankenhaus
Friedrichstr. 41, DE-01067 Dresden
International Faculty
Department of Dermatology, Venerology, Leprosy
Jawaharlal Nehru Medical College
,
Datta Meghe Institute of Higher Education & Research
Premier Deemed to be University
Wardha, Maharashtra, India
Email: uwollina@gmail.com
Literatur
1. Gianfaldoni S, Tchernev G, Wollina U, Fioranelli M, Roccia MG, Gianfaldoni R, Lotti T. An overview of laser in dermatology: the past, the present and … the future (?). Open Access Maced J Med Sci. 2017;5(4):526-530.
2. Anderson RR, Parrish JA. The optics of human skin. J Invest Dermatol. 1981;77(1):13-19.
3. Zhao Z, Fairchild P. Dependence of light transmission through human skin on incident beam diameter at different wavelengths. SPIE Proceedings of Laser-Tissue Interaction IX. 1998;3254:354–360.
4. Chao JR, Porter JP, Hessler J. Cosmetic treatments with energy-based devices in skin of color. Facial Plast Surg. 2023;39(5):496-500.
5. Kutlu Ö, Karadağ AS, Wollina U. Adult acne versus adolescent acne: a narrative review with a focus on epidemiology to treatment. An Bras Dermatol. 2023;98(1):75-83.
6. Boonpethkaew S, Ratanapokasatit Y, Chirasuthat S, Wattanakrai P. Efficacy and safety of the 589/1319 nm solid-state dual-wavelength laser combined with topical benzoyl peroxide for inflammatory acne vulgaris: a split-face randomized controlled trial. Arch Dermatol Res. 2025;317(1):635.
7. Connolly D, Vu HL, Mariwalla K, Saedi N. Acne scarring-pathogenesis, evaluation, and treatment options. J Clin Aesthet Dermatol. 2017;10(9):12-23.
8. Belletti S, Madeddu F, Amoruso GF, Provenzano E, Nisticò SP, Fusco I, Bennardo L. An innovative dual-wavelength laser technique for atrophic acne scar management: a pilot study. Medicina (Kaunas). 2023;59(11):2012.
9. Zhang S, Duan E. Fighting against skin aging: the way from bench to bedside. Cell Transplant. 2018;27(5):729-738.
10. Friedman PM, Dover JS, Chapas A, Jacobson A. Current trends and future directions of the dual 1550-nm erbium glass fiber and 1927-nm thulium fiber non-ablative fractional laser system. Lasers Surg Med. 2025;57(7):561-570.
11. Friedman PM, Dover JS, Chapas A, Rahman Z, Ross EV, Kilmer SL, Roberts WE, Sodha P, Stimmel JB, Moncrief MBC, Waibel JS. 1,550 nm Erbium-doped and 1,927 nm thulium nonablative fractional laser system: best practices and treatment setting recommendations. Dermatol Surg. 2022;48(2):195-200.
12. Belletti S, Madeddu F, Brando A, Provenzano E, Nisticò SP, Fusco I, Bennardo L. Laser impacts on skin rejuvenation: the use of a synergistic emission of CO2 and 1540 nm wavelengths. Medicina (Kaunas). 2023;59(10):1857.
13. Tsur Shenhav L, Shehade W, Muravnik G, Horovitz T, Artzi O. The safety and efficacy of a dual CO2 and 1570-nm hybrid laser for periorbital rejuvenation. Dermatol Surg. 2023;49(5):479-482.
14. Zhang M, Huang Y, Wu Q, Lin T, Gong X, Chen H, Wang Y. Comparison of 1064-nm and dual-wavelength (532/1064-nm) picosecond-domain nd:yag lasers in the treatment of facial photoaging: a randomized controlled split-face study. Lasers Surg Med. 2021;53(9):1158-1165.
15. Vanaman Wilson MJ, Jones IT, Bolton J, Larsen L, Wu DC, Goldman MP. Prospective studies of the efficacy and safety of the picosecond 755, 1,064, and 532 nm lasers for the treatment of infraorbital dark circles. Lasers Surg Med. 2018;50(1):45-50.
16. Guida S, Longo C, Ronga R, Stabile G, Podo Brunetti A, Bigotto GD, Conforti C, Ciardo S, Cantisani C, Paolino G, Mercuri SR, Nisticò SP, Zerbinati N, Rongioletti F, Pellacani G. Melasma and reflectance confocal microscopy: from baseline to treatment monitoring. Int J Dermatol. 2024;63(8):1007-1012. 17. Fioranelli M, Jafferany M, Wollina U, Tirant M, Van Thuong N, Lotti T. New local treatments for different types of melasma: Vascular type vs nonvascular type. A randomized polycentric study. Dermatol Ther. 2020 May;33(3):e13300.
18. Goldman A, Goldust M, Wollina U. Periorbital hyperpigmentation—dark circles under the eyes; treatment suggestions and combining procedures. Cosmetics 2021;8:26.
19. Kim HT, Choi ME, Na H, Lee WJ, Won CH, Lee MW, Choi JH, Chang SE. Partial unilateral lentiginosis: a clinicopathological analysis of 32 cases on the head and neck area in Korea. Int J Dermatol. 2021;60(11):1376-1384.
20. Wollina U, De Cuyper C. Evidence-based medicine in laser-assisted tattoo removal. In: Maibach HI, Gorouhi F (Eds.) Evidence-based Dermatology, 2nd Edition. PMPH-USA: Shelton, CT: 2011: 557-570.
21. Kung KY, Shek SY, Yeung CK, Chan HH. Evaluation of the safety and efficacy of the dual wavelength picosecond laser for the treatment of benign pigmented lesions in Asians. Lasers Surg Med. 2019;51(1):14-22.
22. Choi YJ, Nam JH, Kim JY, Min JH, Park KY, Ko EJ, Kim BJ, Kim WS. Efficacy and safety of a novel picosecond laser using combination of 1 064 and 595 nm on patients with melasma: A prospective, randomized, multicenter, split-face, 2% hydroquinone cream-controlled clinical trial. Lasers Surg Med. 2017;49(10):899-907.
23. Eimpunth S, Wanitphakdeedecha R, Triwongwaranat D, Varothai S, Manuskiatti W. Therapeutic outcome of melasma treatment by dual-wavelength (511 and 578 nm) laser in patients with skin phototypes III-V. Clin Exp Dermatol. 2014;39(3):292-297.
24. Nguyen HT, Doan EVL, Tran TNA, Vu TTP, Phan HN, Sobanko JF. Safety and efficacy of tattoo removal using a dual-wavelength 1064/532-nm picosecond laser in patients with Fitzpatrick skin type III and IV. Lasers Surg Med. 2021;53(7):939-945.
25. Moustafa F, Suggs A, Hamill SS, Friedman PM. Successful treatment of cosmetic eyebrow tattoos in Fitzpatrick III-IV with picosecond (1,064, 532-nm) neodymium-doped yttrium aluminum garnet laser with a perfluorodecalin-infused patch: a pilot study. Lasers Surg Med. 2020;52(7):586-589.
26. Hindritiani R, Widjaya MRH, Puspitosari D, Rizqandaru T, Ruchiatan K. Partial unilateral lentiginosis successfully treated with the combination of 511 nm and 578 nm copper bromide laser in an Indonesian woman. Clin Cosmet Investig Dermatol. 2023;16:2271-2276.
27. Liu G, Jia W, Nelson JS, Chen Z. In vivo, high-resolution, three-dimensional imaging of port wine stain microvasculature in human skin. Lasers Surg Med. 2013;45(10):628-632.
28. Latrive A, Teixeira LR, Gomes AS, Zezell DM. Characterization of skin port-wine stain and hemangioma vascular lesions using Doppler OCT. Skin Res Technol. 2016;22(2):223-229.
29. Trafalski M, Jurczyszyn K. Contemporary methods of treating venous lake lesions on the oral mucosa: A literature review. Adv Clin Exp Med. 2025;34(6):1039-1051.
30. Anzell AR, White C, Diergaarde B, Carlson JC, Roman BL. Hereditary hemorrhagic telangiectasia prevalence estimates calculated from GnomAD allele frequencies of predicted pathogenic variants in ENG and ACVRL1. Circ Genom Precis Med. 2025:e005061. doi: 10.1161/CIRCGEN.124.005061. Epub ahead of print.
31. Wollina U. Recent advances in the understanding and management of rosacea. F1000Prime Rep. 2014 Jul 8;6:50.
32. Periyasamy MK, Sekar CS, Rai R. Effectiveness of dual sequential wavelength laser in the treatment of portwine stains - a retrospective study. Indian Dermatol Online J. 2019;10(4):418-421.
33. Wang T, Chen D, Yang J, Ma G, Yu W, Lin X. Safety and efficacy of dual-wavelength laser (1064 + 595 nm) for treatment of non-treated port-wine stains. J Eur Acad Dermatol Venereol. 2018;32(2):260-264.
34. Peng X, Ye T, Yu B, Liu X, Liu L. Comparing HMME-PDT and Cynergy dual-wavelength laser in the treatment of facial PWS. Photodiagnosis Photodyn Ther. 2022;37:102703.
35. Zhang Y, Zhu J, Shi L, Wang D, Wen L, Miao F, Zhang G, Wang X. Dual wavelength diode laser for the treatment of lower lip venous lakes. Dermatol Ther. 2021;34(1):e14616.
36. Wollina U, Goldman A. The dual 980-nm and 1470-nm diode laser for vascular lesions. Dermatol Ther. 2020;33(4):e13558.
37. Seo HM, Kim JI, Kim HS, Choi YJ, Kim WS. Prospective comparison of dual wavelength long-pulsed 755-nm alexandrite/1,064-nm neodymium:yttrium-aluminum-garnet laser versus 585-nm pulsed dye laser treatment for rosacea. Ann Dermatol. 2016 Oct;28(5):607-614.
38. Cubiró X, Garcia-Melendo C, Morales-Munera CE, Roé-Crespo E, Riera-Mestre A, Mora-Luján JM, Iriarte A, Puig L, Baselga E. Satisfactory treatment of mucocutaneous lesions in hereditary hemorrhagic telangiectasia patients with dual pulsed dye laser and neodymium:yttrium-aluminum-garnet. Dermatol Ther. 2021;34(6):e15124.
