„Laser-assisted drug delivery“: Ein neues Konzept in der Dermatopharmakotherapie

„Laser-assisted drug delivery“: A new concept in dermatopharmacotherapy

Keywords | Summary | Correspondence | Literature


, , , ,


, , , ,


The topical application of pharmacologic agents is an essential part of dermatotherapy. Yet, the (dermal) bioavailability of topically applied drugs is often limited due to the effective barrier function of the stratum corneum. Down this line various more or less successful strategies have been developed to overcome the epidermal barrier. Fractional ablative lasers represent a novel technology that enables a standardized, contact- free penetration of the epidermis, and allow us to increase the bioavailability of topically applied drugs by means of a laser assisted drug delivery (LADD). Here, we present an overview of established as well as perspective applications of LADD in the clinical practice.


Die Behandlung von Hauterkrankungen durch topisch applizierte Externa stellt eine der wichtigsten Therapieoptionen in der Dermatologie dar. Auf Grund der oftmals geringen Bioverfügbarkeit von Lokaltherapeutika wurden bisher zahlreiche Methoden entwickelt die Penetration der Substanzen zu verbessern. Fraktionale ablative Laser stellen ein neuartiges, elegantes Verfahren dar, die dermale Barriere in einer definierten und kontrollierten Art und Weise kontaktfrei zu überwinden, um somit die Penetration von lokal applizierten Pharmaka zu erhöhen und deren dermale Bioverfügbarkeit im Sinne einer laser assisted drug delivery (LADD) zu steigern. Die vorliegende Arbeit bietet einen .berblick über die aktuellen aber auch perspektivischen Einsatzmöglichkeiten der LADD.

Leider haben Sie sich nicht eingeloggt, um den Beitrag lesen zu können. Bitte loggen Sie sich ein oder beantragen Sie Ihre Zugangsberechtigung. Vielen Dank. Weitere Informationen finden Sie hier>


Dr. med. P. A. Gerber, D.A.L.M.
Hautklinik Universit.tsklinikum Düsseldorf
Moorenstra.e 5
D-40225 Düsseldorf

Conflict of Interests

PAG hat Honorare der Firma Asclepion Laser Technologies erhalten. PAG hat finanzielle Unterstützung für Forschungsvorhaben durch die Firma Galderma erhalten. PAG und SAB haben finanzielle Unterstützung für Forschungsvorhaben durch die Firma Leo Pharma erhalten. SAB hat Reisekostenunterstützungen der Firma Biofrontera erhalten.


1. Anderson RR, Donelan MB, Hivnor C, Greeson E, Ross EV, Shumaker PR, Uebelhoer NS, Waibel JS (2014) Laser treatment of traumatic scars with an emphasis on ablative fractional laser resurfacing: consensus report. JAMA Dermatol 150:187-193.
2. Baron ED, Harris L, Redpath WS, Shapiro H, Hetzel F, Morley G, Bar-Or D, Stevens SR (2003) Laser-assisted penetration of topical anesthetic in adults. Arch Dermatol 139:1288-1290.
3. Chen X, Shah D, Kositratna G, Manstein D, Anderson RR, Wu MX (2012) Facilitation of transcutaneous drug delivery and vaccine immunization by a safe laser technology. J Control Release 159:43-51.
4. Farris PK (2005) Topical vitamin C: a useful agent for treating photoaging and other dermatologic conditions. Dermatol Surg 31:814-817; discussion 818. 5. Forster B, Klein A, Szeimies RM, Maisch T (2010) Penetration enhancement of two topical 5-aminolaevulinic acid formulations for photodynamic therapy by erbium:YAG laser ablation of the stratum corneum: continuous versus fractional ablation. Exp Dermatol 19:806-812.
6. Freedman JR, Greene RM, Green JB (2014) Histologic effects of resurfacing lasers. Facial Plast Surg 30:40-48.
7. Issa MC, Kassuga LE, Chevrand NS, Pires MT (2013) Topical delivery of triamcinolone via skin pretreated with ablative radiofrequency: a new method in hypertrophic scar treatment. Int J Dermatol 52:367-370.
8. Kim SK, Park JY, Song HS, Kim YS, Kim YC (2013) Photodynamic therapy with ablative carbon dioxide fractional laser for treating Bowen disease. Ann Dermatol 25:335-339.
9. Lee WR, Pan TL, Wang PW, Zhuo RZ, Huang CM, Fang JY (2008) Erbium:YAG laser enhances transdermal peptide delivery and skin vaccination. J Control Release 128:200-208.
10. Lee WR, Shen SC, Aljuffali IA, Li YC, Fang JY (2013) Impact of Different Vehicles for Laser-Assisted Drug Permeation via Skin: Full-Surface versus Fractional Ablation. Pharm Res.
11. Lee WR, Shen SC, Fang CL, Zhuo RZ, Fang JY (2008) Topical delivery of methotrexate via skin pretreated with physical enhancement techniques: low-fluence erbium:YAG laser and electroporation. Lasers Surg Med 40:468-476.
12. Lee WR, Shen SC, Wang KH, Hu CH, Fang JY (2002) The effect of laser treatment on skin to enhance and control transdermal delivery of 5-fluorouracil. J Pharm Sci 91:1613-1626.
13. Lippert J, Smucler R, Vlk M (2013) Fractional carbon dioxide laser improves nodular basal cell carcinoma treatment with photodynamic therapy with methyl 5-aminolevulinate. Dermatol Surg 39:1202-1208.
14. Manstein D, Herron GS, Sink RK, Tanner H, Anderson RR (2004) Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med 34:426-438.
15. M arra DE, Yip D, Fincher EF, Moy RL (2006) Systemic toxicity from topically applied lidocaine in conjunction with fractional photothermolysis. Arch Dermatol 142:1024-1026.
16. Metelitsa AI, Alster TS (2010) Fractionated laser skin resurfacing treatment complications: a review. Dermatol Surg 36:299-306.
17. Morton CA, Mckenna KE, Rhodes LE, British Association of Dermatologists Therapy G, Audit S, The British Photodermatology G (2008) Guidelines for topical photodynamic therapy: update. Br J Dermatol 159:1245-1266.
18. Murray JC, Burch JA, Streilein RD, Iannacchione MA, Hall RP, Pinnell SR (2008) A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation. J Am Acad Dermatol 59:418-425.
19. Nino M, Calabro G, Santoianni P (2010) Topical delivery of active principles: the field of dermatological research. Dermatol Online J 16:4.
20. O ni G, Brown SA, Kenkel JM (2012) Can fractional lasers enhance transdermal absorption of topical lidocaine in an in vivo animal model? Lasers Surg Med 44:168-174.
21. Sakamoto FH, Lopes JD, Anderson RR (2010) Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part I. Acne vulgaris: when and why consider photodynamic therapy? J Am Acad Dermatol 63:183-193; quiz 193-184.
22. Sandberg C, Halldin CB, Ericson MB, Larko O, Krogstad AL, Wennberg AM (2008) Bioavailability of aminolaevulinic acid and methylaminolaevulinate in basal cell carcinomas: a perfusion study using microdialysis in vivo. Br J Dermatol 159:1170-1176.
23. Shapiro H, Harris L, Hetzel FW, Bar-Or D (2002) Laser assisted delivery of topical anesthesia for intramuscular needle insertion in adults. Lasers Surg Med 31:252-256.
24. Sklar LR, Burnett CT, Waibel JS, Moy RL, Ozog DM (2014) Laser assisted drug delivery: a review of an evolving technology. Lasers Surg Med 46:249-262.
25. Szeimies RM, Lischner S, Philipp-Dormston W, Walker T, Hiepe-Wegener D, Feise K, Podda M, Prager W, Kohl E, Karrer S (2013) Photodynamic therapy for skin rejuvenation: treatment options - results of a consensus conference of an expert group for aesthetic photodynamic therapy. J Dtsch Dermatol Ges 11:632-636.
26. Togsverd-Bo K, Haak CS, Thaysen-Petersen D, Wulf HC, Anderson RR, Haedersdal M (2012) Intensified photodynamic therapy of actinic keratoses with fractional CO2 laser: a randomized clinical trial. Br J Dermatol 166:1262-1269.
27. Togsverd-Bo K, Lei U, Erlendsson AM, Taudorf EH, Philipsen PA, Wulf HC, Skov L, Haedersdal M (2014) Combination of ablative fractional laser and daylight mediated photodynamic therapy for actinic keratosis in organ transplant recipients - a randomized controlled trial. Br J Dermatol.
28. Trelles MA, Leclere FM, Martinez-Carpio PA (2013) Fractional carbon dioxide laser and acoustic-pressure ultrasound for transepidermal delivery of cosmeceuticals: a novel method of facial rejuvenation. Aesthetic Plast Surg 37:965-972.
29. Waibel JS, Wulkan AJ, Shumaker PR (2013) Treatment of hypertrophic scars using laser and laser assisted corticosteroid delivery. Lasers Surg Med 45:135-140.
30. Yoo KH, Kim BJ, Kim MN (2009) Enhanced efficacy of photodynamic therapy with methyl 5-aminolevulinic acid in recalcitrant periungual warts after ablative carbon dioxide fractional laser: a pilot study. Dermatol Surg 35:1927-1932.
31. Yun PL, Tachihara R, Anderson RR (2002) Efficacy of erbium:yttriumaluminum- garnet laser-assisted delivery of topical anesthetic. J Am Acad Dermatol 47:542-547.